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正常小牛淋巴结副皮质区毛细血管后“高内皮微静脉”的电子显微镜研究。

Electron microscopic study of the paracortical postcapillary "high endothelial venules" in lymph nodes of the normal calf.

作者信息

Ohmann H B

出版信息

Cell Tissue Res. 1980;212(3):465-74. doi: 10.1007/BF00236511.

DOI:10.1007/BF00236511
PMID:7459989
Abstract

The structure of the postcapillary "high endothelial venules" (HEV) of lymph nodes in calves was studied light and electron microscopically. These venules were detected light microscopically in the paracortical zone by their high cuboidal endothelium, a distinct basal lamina, the migration of lymphocytes through the vessel wall, and the dominance of lymphoid cells in the lumen, often completely obliterating the latter. Ultrastructurally, the endothelial cells (HEC) of the HEV were characterized by a prominent Golgi complex including many small vesicles, a few lysosome-like bodies, and a specific association between mitochondria and rough endoplasmic reticulum (MER). The HEC are connected by desmosomes, whereas the intimate contact points between migrating lymphocytes and endothelial cells could not be classified according to the well-defined junctional types. Lymphocyte migration occurred predominantly intercellularly, i.e., between endothelial cells. Although the overall appearance of the described vessel type in bovines bears resemblance to HEV in other investigated species, several differences occur that most probably are related to species variation.

摘要

利用光学显微镜和电子显微镜对犊牛淋巴结毛细血管后“高内皮微静脉”(HEV)的结构进行了研究。通过光学显微镜在副皮质区检测到这些微静脉,其具有高立方形内皮、明显的基膜、淋巴细胞穿过血管壁的迁移以及管腔内淋巴细胞占优势,后者常完全阻塞管腔。在超微结构上,HEV的内皮细胞(HEC)的特征是具有一个突出的高尔基体复合体,包括许多小泡、一些溶酶体样小体,以及线粒体与粗面内质网(MER)之间的特定关联。HEC通过桥粒相连,而迁移的淋巴细胞与内皮细胞之间的紧密接触点无法根据明确的连接类型进行分类。淋巴细胞迁移主要发生在细胞间,即在内皮细胞之间。尽管所描述的牛血管类型的总体外观与其他研究物种的HEV相似,但仍存在一些差异,这些差异很可能与物种差异有关。

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本文引用的文献

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The migration of lymphocytes across the vascular endothelium in lymphoid tissue. A reexamination.淋巴细胞在淋巴组织中穿越血管内皮的迁移。重新审视。
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IgG immunoglobulin in the wall of post-capillary venules: possible relationship to lymphocyte recirculation.毛细血管后微静脉壁中的IgG免疫球蛋白:与淋巴细胞再循环的可能关系。
Immunology. 1971 Jan;20(1):115-8.
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The ultrastructure of mouse lymph node venules and the passage of lymphocytes across their walls.小鼠淋巴结小静脉的超微结构以及淋巴细胞穿过其管壁的过程。
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Comparative studies of the paracortical post-capillary venules of normal and nude mice.正常小鼠和裸鼠皮质旁毛细血管后微静脉的比较研究。
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