牛脾脏组织蛋白酶B和D对大鼠肝脏细胞质核糖核酸酶抑制剂的作用

The action of bovine spleen cathepsins B and D on the cytoplasmic ribonuclease inhibitor from rat liver.

作者信息

Fuhge P, Otto K

出版信息

Hoppe Seylers Z Physiol Chem. 1980 Dec;361(12):1781-5. doi: 10.1515/bchm2.1980.361.2.1781.

DOI:10.1515/bchm2.1980.361.2.1781

Abstract

The inactivation by the lysosomal cathepsins B or D of the cytoplasmic neutral ribonuclease inhibitor has been investigated with respect to the required amounts of cathepsin, optimal pH and time course. With a pH optimum between 5 and 5.5, a possible role of these endopeptidases in regulating the inhibitor and, concomitantly, the ribonuclease and RNA concentrations in the cell is discussed.

摘要

关于溶酶体组织蛋白酶B或D对细胞质中性核糖核酸酶抑制剂的失活作用，已针对所需的组织蛋白酶量、最适pH值和时间进程进行了研究。由于最适pH值在5至5.5之间，因此讨论了这些内肽酶在调节抑制剂以及随之调节细胞内核糖核酸酶和RNA浓度方面的可能作用。