Ottaway C A, Manson-Smith D F, Bruce R G, Parrott D M
Immunology. 1980 Dec;41(4):963-71.
The localization of 125I-UdR-labelled mesenteric lymph node cells in the small intestine and the fraction of the cardiac output delivered to this organ in mice has been examined. Concurrent measurements of these two phenomena in normal animals showed that there was a significant correlation between the localization of lymphoblasts and the distribution of regional blood flow along the small intestine. In mice undergoing enteric infection with Trichinella spiralis, however, the nature of the connection between lymphoblast localization and blood flow distribution in the small intestine was altered. More lymphoblast label accumulated in the small intestine of infected mice than in uninfected animals even at stages of the infection when no alteration in the proportion of the cardiac output received by the small intestine had occurred. Enhanced lymphoblast accumulation occurred in different segments of the infected small intestine as the infection proceeded and these changes paralleled the way in which the parasite burden was distributed in the intestine. The kinetics of lymphoblast accumulation in infected and uninfected small intestine was examined under circumstances where the delivery of blood-borne labelled cells was the same. This showed that both increased entry of lymphoblasts and enhanced retention of lymphoblasts occurred in the parasitized small intestine.
已对125I-尿苷标记的肠系膜淋巴结细胞在小鼠小肠中的定位以及输送至该器官的心输出量比例进行了研究。在正常动物中对这两种现象进行的同步测量表明,成淋巴细胞的定位与沿小肠的局部血流分布之间存在显著相关性。然而,在感染旋毛虫的小鼠中,小肠中成淋巴细胞定位与血流分布之间的联系性质发生了改变。即使在感染阶段小肠接受的心输出量比例未发生改变时,感染小鼠小肠中积累的成淋巴细胞标记也比未感染动物的多。随着感染的进展,感染的小肠不同节段出现成淋巴细胞积累增强,这些变化与寄生虫在肠道中的分布方式平行。在血源性标记细胞输送相同的情况下,研究了感染和未感染小肠中成淋巴细胞积累的动力学。这表明在被寄生的小肠中,成淋巴细胞的进入增加和滞留增强均会发生。