Dick W, Theilmann L
Padiatr Padol. 1980;15(4):345-50.
Urinary levels of lysozyme activity were measured in 32 children afflicted with acute or chronic urinary tract infection and compared to a group of 30 healthy subjects. A significant difference in the levels of lysozyme activity between the two groups could be observed. In the subjects with acute urinary tract infection the lysozyme levels in the urine were additionally determined at the beginning of the therapy, on the third day, the tenth day and three days after cessation of therapy. High lysozyme levels encountered at the onset of the infection showed under therapy a clear tendency to decrease and in all cases no lysozyme was present three days after therapy was completed. The possible causes of the pathological lysozymuria are discussed. The determination of lysozyme is thus an additional method by which to control the course and outcome of urinary tract infections.
对32名患有急慢性尿路感染的儿童测定了尿液中的溶菌酶活性水平，并与30名健康受试者组成的对照组进行了比较。两组之间溶菌酶活性水平存在显著差异。对于患有急性尿路感染的受试者，在治疗开始时、第三天、第十天以及治疗停止三天后，额外测定了尿液中的溶菌酶水平。感染开始时遇到的高溶菌酶水平在治疗过程中呈现明显下降趋势，并且在治疗完成三天后所有病例中均未检测到溶菌酶。文中讨论了病理性溶菌酶尿的可能原因。因此，溶菌酶的测定是控制尿路感染病程和结果的一种辅助方法。
