Effect of oral meclofenamic acid on uterine motility and reactivity to oxytocin in goats.

Spontaneous uterine motility and reactivity to intravenous oxytocin were recorded in eight ovariectomised, oestrogen-primed goats before and after oral meclofenamic acid treatment. Spontaneous motility was completely abolished within 50 to 100 min of meclofenamate administration. However, although uterine reactivity to oxytocin was significantly reduced, the sensitivity was not altered. It is suggested that, in the goat, oxytocin has two effects on the uterus: it increases myometrial activity and also stimulates prostaglandin synthesis.