Fossum S, Smith M E, Bell E B, Ford W L
Scand J Immunol. 1980;12(5):421-32. doi: 10.1111/j.1365-3083.1980.tb00086.x.
The lymph nodes (LN) of the congenitally athymic nude rat(rnu) were compared with the LN of non-nude littermates. The mesenteric and coeliac LN were smaller in the rnu rats, but the axillary and the cervical LN were larger. Germinal centres were found in the LN of nude rats. They were scarce and often very small, but some were of normal structure, especially in the cervical LN. The endothelium of post-capillary venules in the LN or normal rats, was seen. The paracortex was extremely depleted of lymphocytes but remained a distinct area occupied predominantly by pale interdigitating cells. In some LN the medullary sinuses were distended and the cords engorged with plasma cells. The predominant cells in thoracic duct lymph were immunoglobulin-positive B lymphocytes. The hourly output of these cells was the same as that in non-nude littermates. However, small numbers of thoracic duct cells were positive for the markers identified by the monoclonal antibodies W3/13 and W3/25, although in normal rats these are not expressed on small B lymphocytes.
将先天性无胸腺裸鼠（rnu）的淋巴结（LN）与非裸同窝仔鼠的淋巴结进行比较。rnu大鼠的肠系膜淋巴结和腹腔淋巴结较小，但腋窝淋巴结和颈部淋巴结较大。在裸鼠的淋巴结中发现了生发中心。它们稀少且通常非常小，但有些结构正常，尤其是在颈部淋巴结中。观察到正常大鼠淋巴结中毛细血管后微静脉的内皮。副皮质区淋巴细胞极度减少，但仍是一个明显的区域，主要由淡染的交错突细胞占据。在一些淋巴结中，髓窦扩张，索状结构充满浆细胞。胸导管淋巴中的主要细胞是免疫球蛋白阳性B淋巴细胞。这些细胞的每小时输出量与非裸同窝仔鼠相同。然而，少量胸导管细胞对单克隆抗体W3/13和W3/25识别的标志物呈阳性，尽管在正常大鼠中这些标志物不在小B淋巴细胞上表达。
