棕榈酸对体外敌敌畏抑制的血浆胆碱酯酶活性再生的影响。

Effect of palmitic acid on regeneration of dichlorovos-inhibited plasma cholinesterase activity in vitro.

作者信息

Purshottam T, Kaveeshwar U

出版信息

Aviat Space Environ Med. 1980 Oct;51(10):1134-8.

Abstract

Free fatty acids (FFA) in plasma were observed to be significantly increased (p less than 0.001) in high fat diet (HFD) rats and albumin significantly decreased (p less than 0.001) in low protein diet (LPD) rats. Dichlorovos was more toxic to HFD and LPD rats, compared to high protein diet (HPD) and standard diet (SD) rats, but these differences were not statistically significant. The spontaneous regeneration of dichlorovos-inhibited plasma cholinesterase activity in vivo was faster in the HFD rats compared to the other three dietary groups. Adding palmitic acid (PA) in vitro to the plasma system, at PA/albumin molar ratios in the range 0.53:2.83, accelerated spontaneous regeneration of dichlorovos-inhibited plasma cholinesterase activity significantly during 2-24 h periods. PA acceleration of enzyme regeneration rate did not appear to be related to PA interactions with dichlorovos-albumin binding in plasma.

摘要

观察发现，高脂饮食（HFD）大鼠血浆中的游离脂肪酸（FFA）显著增加（p<0.001），而低蛋白饮食（LPD）大鼠的白蛋白显著降低（p<0.001）。与高蛋白饮食（HPD）和标准饮食（SD）大鼠相比，敌敌畏对HFD和LPD大鼠的毒性更大，但这些差异无统计学意义。与其他三个饮食组相比，HFD大鼠体内敌敌畏抑制的血浆胆碱酯酶活性的自发恢复更快。在体外向血浆系统中添加棕榈酸（PA），当PA/白蛋白摩尔比在0.53:2.83范围内时，在2-24小时内显著加速了敌敌畏抑制的血浆胆碱酯酶活性的自发恢复。PA对酶再生速率的加速作用似乎与PA与血浆中敌敌畏-白蛋白结合的相互作用无关。