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补体介导的溶血动力学。ii.——新方程的推导

Kinetics of haemolysis by complement. ii.--Development of new equations.

作者信息

Arquembourg P C, Burl B A

出版信息

Ann Immunol (Paris). 1978 Oct-Dec;129 C(6):831-41.

PMID:747388
Abstract

A new quantitative equation was developed by a process of trial and error. This equation, more complex than the classic Von Krogh equation, nevertheless gives a better account of percentages of haemolysis versus quantities of complement. A basic biological unit independent of red corpuscles quantity and sensitivity can be calculated. In addition, variations of the slope coefficient are of interest in pathology. However, the present paper is devoted to "normal" complement kinetics. Time-kinetics were found to follow the rules of general chemistry and could be derived mathematically.

摘要

通过反复试验的过程得出了一个新的定量方程。这个方程比经典的冯·克罗格方程更复杂,但能更好地解释溶血百分比与补体数量之间的关系。可以计算出一个独立于红细胞数量和敏感性的基本生物学单位。此外,斜率系数的变化在病理学中很有意义。然而,本文致力于研究“正常”补体动力学。发现时间动力学遵循普通化学的规律,并且可以通过数学推导得出。

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