N-辛酰基γ-氨基丁酸的抗溃疡及胃分泌活性

Antiulcer and gastric secretory activity of N-octanoyl gamma-aminobutyric acid.

作者信息

Sen S, Habibuddin M, Pal S P

机构信息

Department of Pharmaceutical Technology Jadavpur University, Calcutta, India.

出版信息

Life Sci. 1995;57(20):1877-85. doi: 10.1016/0024-3205(95)02168-i.

DOI:10.1016/0024-3205(95)02168-i

PMID:7475935

Abstract

A new gamma-aminobutyric acid derivative synthesised in this laboratory, N-octanoyl gamma-aminobutyric acid was found to possess antinociceptive activity but no anticonvulsant activity. The effect of the compound on gastric lesions produced by aspirin, ethanol and stress in rats, was studied and the compound was found to possess effective antiulcer action. Even though, N-octanoyl gamma-aminobutyric acid did not produce a significant change in the volume of gastric acid secretion, however, it decreased the acidity and peptic activity and significantly enhanced the gastric mucus secretion.

摘要

本实验室合成的一种新的γ-氨基丁酸衍生物N-辛酰基γ-氨基丁酸被发现具有抗伤害感受活性，但无抗惊厥活性。研究了该化合物对大鼠阿司匹林、乙醇和应激所致胃损伤的影响，发现该化合物具有有效的抗溃疡作用。尽管N-辛酰基γ-氨基丁酸对胃酸分泌量没有显著影响，然而，它降低了酸度和胃蛋白酶活性，并显著增强了胃黏液分泌。