哮喘患者自发性支气管收缩期间的血浆心钠素

Plasma atrial natriuretic peptide during spontaneous bronchoconstriction in asthmatics.

作者信息

Robichaud A, Michoud M C, Hamet P, du Souich P

机构信息

Département de Pharmacologie, Faculté de Médecine, Université de Montréal, Québec, Canada.

出版信息

Peptides. 1995;16(4):653-6. doi: 10.1016/0196-9781(95)00023-d.

DOI:10.1016/0196-9781(95)00023-d

PMID:7479299

Abstract

The aim of this work was to establish the role of endogeneous ANP during a spontaneous asthma attack. Forced expiratory lung volume in 1 s (FEV1), cardiovascular parameters, and plasma ANP, cAMP, and cGMP were measured for 60 min before and 10 min after treatment with a bronchodilator in 10 asthmatics. The results show that in the presence of moderate bronchoconstriction, FEV1 was 54 +/- 3% (+/-SE); ANP levels initially were slightly elevated at 47 +/- 10 pg/ml and decreased to 26 +/- 3 pg/ml (p < 0.05) over 60 min, with no change in FEV1. Following salbutamol inhalation, FEV1 increased to 77 +/- 4% with no change in ANP. We conclude that endogenous ANP does not act as a bronchodilator in asthmatics with moderate bronchospasm.

摘要

这项工作的目的是确定内源性心钠素在自发性哮喘发作期间的作用。对10名哮喘患者在使用支气管扩张剂治疗前60分钟和治疗后10分钟测量了1秒用力呼气肺容积（FEV1）、心血管参数以及血浆心钠素、环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）。结果显示，在存在中度支气管收缩的情况下，FEV1为54±3%（±标准误）；心钠素水平最初略有升高，为47±10皮克/毫升，并在60分钟内降至26±3皮克/毫升（p<0.05），而FEV1无变化。吸入沙丁胺醇后，FEV1增加到77±4%，心钠素无变化。我们得出结论，内源性心钠素在患有中度支气管痉挛的哮喘患者中不作为支气管扩张剂起作用。