Jamison J H, Kaplan D W, Hamman R, Eagar R, Beach R, Douglas J M
Department of Public Health, Denver Department of Health & Hospitals, Colorado, USA.
Sex Transm Dis. 1995 Jul-Aug;22(4):236-43. doi: 10.1097/00007435-199507000-00007.
Human papillomavirus infection is a sexually transmitted disease associated with cervical dysplasia and carcinoma.
To determine prevalence rates of cervical human papillomavirus infection compared with other sexually transmitted diseases and risk factors associated with human papillomavirus infection among adolescent women, we evaluated 634 patients attending three urban adolescent clinics.
Patient evaluation included Pap smears; screening for chlamydia, gonorrhea, and trichomoniasis; and testing of cervical swab samples for human papillomavirus DNA.
Cervical human papillomavirus was the most common STD in our population (15.6%), followed by infection with Chlamydia trachomatis (11.0%), Neisseria gonorrhoeae (7.1%), and Trichomonas vaginalis (5.4%). The most prevalent human papillomavirus types were 16/18 (7.3%), followed by 31/33/35 (4.7%) and 6/11 (3.5%). When genital warts on exam, low-grade squamous intraepithelial lesions on cytology, or cervical human papillomavirus DNA were considered as indicators of genital human papillomavirus infection, 24% of patients had any manifestation of infection, including 15% with clinically apparent infection (genital warts), 36% with cytologically apparent infection without warts, and 49% with subclinical infection only (cervical human papillomavirus DNA without low-grade squamous intraepithelial lesions or warts). Factors associated with detection of cervical human papillomavirus DNA by multivariate analysis included number of lifetime sexual partners and genital warts on exam.
Cervical human papillomavirus infection was the most prevalent sexually transmitted disease among an ethnically diverse group of urban adolescent females, with a large proportion of infections neither clinically nor cytologically apparent. The strong association with lifetime sexual partners substantiates that cervical human papillomavirus is acquired predominantly by sexual contact and often soon after the onset of sexual activity.
人乳头瘤病毒感染是一种与宫颈发育异常和癌相关的性传播疾病。
为了确定与其他性传播疾病相比，青少年女性宫颈人乳头瘤病毒感染的患病率以及与人乳头瘤病毒感染相关的危险因素，我们评估了在三家城市青少年诊所就诊的634例患者。
患者评估包括巴氏涂片；衣原体、淋病和滴虫病筛查；以及宫颈拭子样本中人乳头瘤病毒DNA检测。
宫颈人乳头瘤病毒是我们研究人群中最常见的性传播疾病（15.6%），其次是沙眼衣原体感染（11.0%）、淋病奈瑟菌感染（7.1%）和阴道毛滴虫感染（5.4%）。最常见的人乳头瘤病毒类型是16/18型（7.3%），其次是31/33/35型（4.7%）和6/11型（3.5%）。当将检查时的尖锐湿疣、细胞学检查中的低级别鳞状上皮内病变或宫颈人乳头瘤病毒DNA视为生殖器人乳头瘤病毒感染的指标时，24%的患者有任何感染表现，包括15%有临床明显感染（尖锐湿疣），36%有细胞学明显感染但无疣体，49%仅有亚临床感染（宫颈人乳头瘤病毒DNA阳性但无低级别鳞状上皮内病变或疣体）。多因素分析显示，与检测到宫颈人乳头瘤病毒DNA相关的因素包括终身性伴侣数量和检查时的尖锐湿疣。
在种族多样的城市青少年女性群体中，宫颈人乳头瘤病毒感染是最常见的性传播疾病，很大一部分感染在临床和细胞学上均不明显。与终身性伴侣数量的强关联证实，宫颈人乳头瘤病毒主要通过性接触获得，且常在性活动开始后不久感染。
