Andersen G, Vestergaard K, Ingemann-Nielsen M, Lauritzen L
Department of Neurology, Aalborg Hospital, Denmark.
Acta Psychiatr Scand. 1995 Sep;92(3):193-8. doi: 10.1111/j.1600-0447.1995.tb09567.x.
An unselected cohort of 285 stroke patients, median age 69 years, were studied for correlation between potential risk factors and the 1-year incidence of post-stroke depression (PSD). The following factors correlated significantly with PSD: a history of previous stroke, a history of previous depression, female gender, living alone and social distress prestroke. Further, social inactivity, decrease in social activity, pathological crying and intellectual impairment at 1 month but not functional outcome correlated to PSD. A multivariate regression analysis showed that intellectual impairment explained 42% of variance of mood score. Major depression was unrelated to lesion location. We conclude that etiology to PSD is a complex mixture of prestroke personal and social factors, and stroke induced social, emotional and intellectual handicap.
对285例中风患者（中位年龄69岁）的非选择性队列进行研究，以探讨潜在风险因素与中风后抑郁（PSD）1年发病率之间的相关性。以下因素与PSD显著相关：既往中风史、既往抑郁史、女性、独居和中风前的社会困扰。此外，1个月时的社交不活动、社交活动减少、病理性哭泣和智力障碍与PSD相关，但功能结局与之无关。多变量回归分析表明，智力障碍解释了情绪评分方差的42%。重度抑郁与病变部位无关。我们得出结论，PSD的病因是中风前个人和社会因素以及中风引起的社会、情感和智力障碍的复杂混合。
