Elovic R P, Hipp J A, Hayes W C
Department of Restorative Dentistry, Harvard School of Dental Medicine, Boston, Massachusetts, USA.
J Bone Miner Res. 1995 Jul;10(7):1087-93. doi: 10.1002/jbmr.5650100713.
Although osteoporosis is a major public health concern, its effect on oral bone has not been determined. More important may be the effect of estrogen depletion on the response of oral bone to dental treatments such as tooth extraction or pathologic processes such as periodontal disease. Our objective was to determine if maxillary molar extraction increases mandibular bone loss in the ovariectomized compared with a sham-operated control. Fifty-three ovariectomized and 53 sham-operated 6-month-old Sprague-Dawley rats were randomly assigned to the following groups: (1) ovariectomized, adult; (2) sham-operated, adult; (3) ovariectomized, adult, extraction; (4) sham-operated, adult, extraction; (5) ovariectomized, old; (6) sham-operated, old; (7) ovariectomized, old, extraction; and (8) sham-operated, old, extraction. Fourteen days following ovariectomy, the extraction groups had their bilateral maxillary molars extracted. The adult and old rats were sacrificed 114 and 200 days postovariectomy, respectively. The right mandible was tested to failure in three point bending. The bone mineral density (BMD) of the left mandible was measured with high resolution dual energy X-ray absorptiometry. The area fraction and area moment of inertia of mandible sections were determined using image processing software. In the ovariectomized rats, maxillary molar extraction resulted in decreases (p < 0.05) in the failure load (21%), stiffness (39%), BMD (3%), and bone area fraction (8%) of the mandible. However, in the sham-operated rats, these decreases following maxillary molar extraction were less (p < 0.05) than those in the ovariectomized rats and only present in the mandibles of the aged rats.(ABSTRACT TRUNCATED AT 250 WORDS)
尽管骨质疏松是一个重大的公共卫生问题，但其对口腔骨的影响尚未确定。雌激素缺乏对口腔骨对诸如拔牙等牙科治疗或诸如牙周病等病理过程的反应的影响可能更为重要。我们的目的是确定与假手术对照组相比，上颌磨牙拔除是否会增加去卵巢大鼠的下颌骨丢失。将53只去卵巢和53只假手术的6月龄Sprague-Dawley大鼠随机分为以下几组：(1)去卵巢成年组；(2)假手术成年组；(3)去卵巢成年拔牙组；(4)假手术成年拔牙组；(5)去卵巢老年组；(6)假手术老年组；(7)去卵巢老年拔牙组；(8)假手术老年拔牙组。去卵巢14天后，拔牙组双侧上颌磨牙被拔除。成年和老年大鼠分别在去卵巢后114天和200天处死。对右侧下颌骨进行三点弯曲试验直至破坏。用高分辨率双能X线吸收法测量左侧下颌骨的骨密度(BMD)。使用图像处理软件确定下颌骨切片的面积分数和面积惯性矩。在去卵巢大鼠中，上颌磨牙拔除导致下颌骨的破坏载荷(21%)、刚度(39%)、BMD(3%)和骨面积分数(8%)降低(p<0.05)。然而，在假手术大鼠中，上颌磨牙拔除后的这些降低程度(p<0.05)比去卵巢大鼠小，且仅在老年大鼠的下颌骨中出现。(摘要截断于250字)
