Shevchenko V A, Semov A B, Akaeva E A, Elisova T V, Iofa E L, Nilova I N, Stephan G, Romm H, Burkart W
Radiats Biol Radioecol. 1995 Sep-Oct;35(5):646-54.
Frequency of chromosome aberration was evaluated in 537 persons taken part in amelioration after the accident. The highest rate of aberration was found in covering builders and dosimetric: 3.24 +/- 0.25 and 3.11 +/- 0.43 per 100 cells, respectively. The mean rate of aberrations among the Chernobyl NPP staff was 2.37 +/- 0.20 per 100 cells, in the other examined groups the mean yield of aberration varied from 1.31 to 1.47 per 100 cells. The found aberration rates correspond to the equivalent whole body doses in the range from 131 to 515 mGy as evaluated by the established dose-response curve. In the group of covering builders the individual aberration rates varied more markedly, and corresponded to the equivalent whole body dose up to about 1 Gy. Slides of 27 individuals were checked by an automated dicentric scoring system. The results showed a satisfactory correlation between the frequencies of dicentrics per chromosome detected by routine and computer methods.
对537名事故后参与康复治疗的人员的染色体畸变频率进行了评估。在掩体建造工人和剂量测定人员中发现的畸变率最高,分别为每100个细胞3.24±0.25和3.11±0.43。切尔诺贝利核电站工作人员群体中的畸变平均率为每100个细胞2.37±0.20,在其他受检群体中,畸变平均发生率在每100个细胞1.31至1.47之间。根据既定的剂量反应曲线评估,所发现的畸变率相当于全身剂量在131至515毫戈瑞范围内。在掩体建造工人组中,个体畸变率变化更为明显,相当于全身剂量高达约1戈瑞。通过自动双着丝粒评分系统检查了27人的玻片。结果表明,常规方法和计算机方法检测到的每条染色体双着丝粒频率之间存在令人满意的相关性。