通过5-氨基乙酰丙酸诱导的卟啉荧光检测早期膀胱癌
Detection of early bladder cancer by 5-aminolevulinic acid induced porphyrin fluorescence.
作者信息
Kriegmair M, Baumgartner R, Knüchel R, Stepp H, Hofstädter F, Hofstetter A
机构信息
Department of Urology, University of Munich, Germany.
出版信息
J Urol. 1996 Jan;155(1):105-9; discussion 109-10.
PURPOSE
We determined whether the sensitivity of detecting dysplasia or early bladder cancer can be improved by 5-aminolevulinic acid induced porphyrin fluorescence.
MATERIALS AND METHODS
A 3% 5-aminolevulinic acid solution was instilled intravesically before cystoscopy in 104 patients. The 5-aminolevulinic acid induced porphyrin fluorescence was excited by violet light from a krypton ion laser (wavelength 406.7 nm.).
RESULTS
The sensitivity of the fluorescence cystoscopy (96.9%) was significantly (p < 0.0001) greater than that of white light cystoscopy (72.7%). There was no impact on specificity.
CONCLUSIONS
Due to the high sensitivity of the procedure fluorescence guided biopsies are recommended instead of random biopsies.
目的
我们确定了通过5-氨基乙酰丙酸诱导的卟啉荧光能否提高检测发育异常或早期膀胱癌的敏感性。
材料与方法
104例患者在膀胱镜检查前膀胱内灌注3%的5-氨基乙酰丙酸溶液。5-氨基乙酰丙酸诱导的卟啉荧光由氪离子激光发出的紫光（波长406.7nm）激发。
结果
荧光膀胱镜检查的敏感性（96.9%）显著高于白光膀胱镜检查（72.7%）（p<0.0001）。对特异性没有影响。
结论
由于该检查方法具有高敏感性，建议采用荧光引导活检而非随机活检。
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