Salloum I M, Cornelius J R, Daley D C, Thase M E
Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213-2593, USA.
Psychopharmacol Bull. 1995;31(2):305-10.
The aim of this study was to assess the usefulness of an objective rating scale (the modified Clinical Institute Withdrawal Assessment for Alcohol [CIWA-A]) and a diazepam loading dose (20 mg) in the management of alcohol withdrawal among hospitalized psychiatric patients. The sample consisted of 152 adult, hospitalized, psychiatric patients with comorbid alcohol dependence. Of the 152 subjects, 115 (75.7%) completed detoxification with supportive therapy only. Among the 37 patients who required pharmacotherapy (24%), 15 (40.5%) required only one 20-mg dose of diazepam, 14 (38%) required 40 mg to 100 mg, and 8 (21.6%) required doses ranging from 120 mg to 220 mg. There were no complications related to this treatment. The results suggest that the use of the objective rating scale and the diazepam loading dose appears to be safe and effective, and is a useful method for the management of alcohol withdrawal among psychiatric patients.
本研究的目的是评估一种客观评定量表(改良的酒精戒断临床研究所评定量表[CIWA - A])和地西泮负荷剂量(20毫克)在住院精神病患者酒精戒断管理中的效用。样本包括152名患有酒精依赖合并症的成年住院精神病患者。在这152名受试者中,115名(75.7%)仅通过支持性治疗完成了脱毒。在37名需要药物治疗的患者中(24%),15名(40.5%)仅需要一剂20毫克的地西泮,14名(38%)需要40毫克至100毫克,8名(21.6%)需要120毫克至220毫克的剂量。该治疗未出现相关并发症。结果表明,使用客观评定量表和地西泮负荷剂量似乎是安全有效的,并且是管理精神病患者酒精戒断的一种有用方法。