Baumann S, Geier S A, Thoma-Gerber E, Noehl M A, Klauss V, Goebel F D
University Eye Hospital Munich, Germany.
Ger J Ophthalmol. 1995 Jul;4(4):239-45.
Ocular microangiopathic syndrome including retinal and conjunctival abnormalities is frequently found in patients with human immunodeficiency virus type 1 (HIV-1) disease. Kaposi's sarcoma (KS) is the most frequent neoplasia found in patients with HIV-1 disease. We have recently reported a significant association between conjunctival microvasculopathy and KS in 117 patients with HIV-1 disease. The objective of the present study was to determine whether this association is existent when matched patients with and without KS are compared. A total of 22 matched pairs were obtained under consideration of the absolute CD4+ lymphocyte count, Walter Reed (WR) classification, gender, and serum levels of beta-2-microglobulin and neopterin. Conjunctival microangiopathy was determined for each eye by a standardized rating scale ranging from 0 to 5, allowing a reliable and valid quantification of conjunctival blood-flow sludging. The mean value obtained for conjunctival sludge was 1.8 (SEM, 0.4) for patients without KS and 3.2 (SEM, 0.3) for patients with KS, demonstrating a clinically and statistically significant difference between the two groups (Student's t = 3.0; P = 0.003). This difference was higher when patients with a CD4+ lymphocyte count exceeding 200/microliters were regarded. Similar factors or mechanisms may contribute to HIV-related conjunctival microvasculopathy and KS.
眼部微血管病变综合征，包括视网膜和结膜异常，在1型人类免疫缺陷病毒（HIV-1）疾病患者中经常被发现。卡波西肉瘤（KS）是HIV-1疾病患者中最常见的肿瘤。我们最近报道了117例HIV-1疾病患者结膜微血管病变与KS之间存在显著关联。本研究的目的是确定在比较匹配的有KS和无KS患者时这种关联是否存在。在考虑绝对CD4 +淋巴细胞计数、沃尔特·里德（WR）分类、性别以及β-2-微球蛋白和新蝶呤的血清水平的情况下，共获得了22对匹配病例。通过从0到5的标准化评分量表确定每只眼睛的结膜微血管病变，从而能够可靠且有效地量化结膜血流淤滞情况。无KS患者结膜淤滞的平均值为1.8（标准误，0.4），有KS患者为3.2（标准误，0.3），两组之间在临床和统计学上均有显著差异（学生t检验= 3.0；P = 0.003）。当考虑CD4 +淋巴细胞计数超过200/微升的患者时，这种差异更大。相似的因素或机制可能导致与HIV相关的结膜微血管病变和KS。
