杆菌肽在肠道中有吸收增强作用吗？

Does bacitracin have an absorption-enhancing effect in the intestine?

作者信息

Gotoh S, Nakamura R, Nishiyama M, Fujita T, Yamamoto A, Muranishi S

机构信息

Department of Biopharmaceutics, Kyoto Pharmaceutical University, Japan.

出版信息

Biol Pharm Bull. 1995 May;18(5):794-6. doi: 10.1248/bpb.18.794.

DOI:10.1248/bpb.18.794

PMID:7493005

Abstract

We studied the absorption enhancement effects of three types of protease inhibitors, aprotinin, bacitracin and soybean trypsin inhibitor, in the rat intestine. Of these protease inhibitors, bacitracin enhanced the absorption of FD-4 and phenol red from the rat small and large intestine without mucosal toxicity. Thus, it was suggested that bacitracin has not only a protease-inhibitory but also an absorption-enhancing capability.

摘要

我们研究了三种蛋白酶抑制剂，即抑肽酶、杆菌肽和大豆胰蛋白酶抑制剂在大鼠肠道中的吸收增强作用。在这些蛋白酶抑制剂中，杆菌肽可增强大鼠小肠和大肠对FD-4和酚红的吸收，且无黏膜毒性。因此，提示杆菌肽不仅具有蛋白酶抑制能力，还具有吸收增强能力。