Breitz H B, Durham J S, Fisher D R, Weiden P L
NeoRx-Virginia Mason Clinical Research Unit, Seattle, Washington 98111, USA.
Cancer Res. 1995 Dec 1;55(23 Suppl):5817s-5822s.
The radiation-absorbed dose was estimated following i.p. administration of a 186Re-labeled murine antibody, NR-LU-10, in 27 patients with advanced ovarian cancer. Data for the dosimetry estimation were obtained from quantitative gamma camera imaging and gamma counting of serum and i.p. fluid radioactivity. A peritoneal cavity model was used to estimate the dose to normal organs from radioactivity within the peritoneal cavity. Estimates of radiation-absorbed dose to normal organs in rad/mCi administered (mean + SD) were: whole body, 0.7 + 0.3; marrow, 0.4 + 0.1; liver, 1.9 + 0.9; kidneys, 0.2 + 0.2, and intestine, 0.2 + 0.2. The radiation-absorbed dose estimates to the normal peritoneal surface varied depending on the volume of fluid infused and whether the activity was measured by the gamma camera or from the peritoneal fluid samples. Using gamma camera data, the peritoneal surface dose ranged from 7 to 36 rads/mCi; when using the peritoneal fluid sample data, the dose ranged from 2 to 25 rads/mCi. Myelosuppression, observed in several patients, correlated best with marrow dose estimates based on the serum radioactivity, and significant toxicity was observed at marrow doses greater than 100 rads. The noninvasive methods of dose estimation for i.p. administration of radioimmunoconjugates provided reasonable absorbed dose estimates when compared with previously described, more invasive methods.
在27例晚期卵巢癌患者腹腔注射186Re标记的鼠源抗体NR-LU-10后，估算了辐射吸收剂量。剂量测定估算的数据来自定量γ相机成像以及血清和腹腔液放射性的γ计数。采用腹腔模型估算腹腔内放射性对正常器官的剂量。正常器官每注射1毫居里（mCi）的辐射吸收剂量估算值（均值±标准差）为：全身，0.7±0.3；骨髓，0.4±0.1；肝脏，1.9±0.9；肾脏，0.2±0.2；肠道，0.2±0.2。正常腹膜表面的辐射吸收剂量估算值因注入液体的体积以及活性是通过γ相机测量还是通过腹膜液样本测量而有所不同。使用γ相机数据时，腹膜表面剂量范围为7至36拉德/毫居里；使用腹膜液样本数据时，剂量范围为2至25拉德/毫居里。在数名患者中观察到的骨髓抑制与基于血清放射性的骨髓剂量估算值相关性最佳，并且在骨髓剂量大于100拉德时观察到显著毒性。与先前描述的更具侵入性的方法相比，腹腔注射放射免疫缀合物的非侵入性剂量估算方法提供了合理的吸收剂量估算值。
