5号染色体异常与透明细胞肾细胞癌中预后较好的形态学特征相关。
Abnormalities of chromosome 5q correlate with morphologic features of better prognosis in clear cell renal carcinomas.
作者信息
Podolski J, Huzarski T, Byrski T, Tołoczko A, Wrzecion S, Sikorski A, Mahoy P, Huebner K, Rabbitts P, Lubiński J
机构信息
Department of Genetics and Pathology, Medical Academy, Szczecin.
出版信息
Pol J Pathol. 1995;46(3):163-6.
Aberrations of the long arm of chromosome 5 (5q) were studied in 79 clear cell renal carcinomas (clear cell RCC) by LOH (loss of heterozygosity) method, using microsatellite markers D5S107, CRTL1, LNS-CA, IL-9.RP1, CFS1R and GeneScan analysis software. Alterations of chromosome 5q were detected in 42% of cases. We found, that accumulation of genomic abnormalities at multiple loci of 5q, especially in 5q21-qter region, where genes for cytokines are located, correlates with morphologic features of better prognosis.
运用微卫星标记D5S107、CRTL1、LNS - CA、IL - 9.RP1、CFS1R以及基因扫描分析软件，通过杂合性缺失（LOH）方法，对79例透明细胞肾细胞癌（透明细胞RCC）患者的5号染色体长臂（5q）畸变情况进行了研究。42%的病例检测到5q染色体改变。我们发现，5q多个位点，尤其是5q21 - qter区域（细胞因子基因所在区域）基因组异常的积累，与预后较好的形态学特征相关。
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