Cardoso C M, De Meis L
Departamento de Bioquímica, Universidade Federal do Rio de Janeiro, Brasil.
Biochem J. 1993 Nov 15;296 ( Pt 1)(Pt 1):49-52. doi: 10.1042/bj2960049.
The fatty acids palmitic (C16:0), stearic (C18:0), arachidic (C20:0) and arachidonic (C20:4) acids inhibit Ca2+ uptake and enhance Ca2+ efflux measured in vesicles derived from the sarcoplasmic reticulum of skeletal muscle. These effects of the fatty acids are impaired by the Ca(2+)-ATPase ligands Mg2+, Ca2+ and K+, and by drugs that block the leakage of Ca2+ through the Ca(2+)-ATPase such as Ruthenium Red, spermine [de Meis (1991) J. Biol. Chem. 266, 5736-5742] and thapsigargin [de Meis and Inesi (1992) FEBS Lett. 299, 33-35].
棕榈酸(C16:0)、硬脂酸(C18:0)、花生酸(C20:0)和花生四烯酸(C20:4)可抑制从骨骼肌肌浆网衍生的囊泡中测得的Ca2+摄取,并增强Ca2+外流。脂肪酸的这些作用会受到Ca(2+)-ATP酶配体Mg2+、Ca2+和K+以及诸如钌红、精胺[德梅斯(1991年)《生物化学杂志》266, 5736 - 5742]和毒胡萝卜素[德梅斯和伊内西(1992年)《欧洲生物化学学会联合会快报》299, 33 - 35]等阻断Ca2+通过Ca(2+)-ATP酶泄漏的药物的损害。