脑毛细血管（血脑屏障）反腔膜中的机械敏感非选择性阳离子通道。
Mechanosensitive nonselective cation channels in the antiluminal membrane of cerebral capillaries (blood-brain barrier).
作者信息
Popp R, Hoyer J, Gögelein H
机构信息
Max-Planck-Institut für Biophysik, Frankfurt, FRG.
出版信息
EXS. 1993;66:101-5. doi: 10.1007/978-3-0348-7327-7_7.
Single stretch-activated (SA) cation channels have been investigated in the antiluminal membrane of freshly isolated brain capillaries. SA-channels did not distinguish between K+ and Na+ ions and were also permeable to Ca2+ and Ba2+ ions. With monovalent cations in the patch pipette the single-channel conductance was 37 pS and with the divalent cations Ba2+ and Ca2+ slope conductance was 16 and 19 pS, respectively. The open probability of the SA-channel increased with increasing negative pressure as well as with depolarization. Cell swelling induced by hypotonic shock activated the SA-channels in cell-attached experiments. The contribution of SA-channels to the regulation of cerebrospinal fluid in brain edema is discussed.
在新鲜分离的脑毛细血管的抗腔膜中对单拉伸激活（SA）阳离子通道进行了研究。SA通道不能区分K⁺和Na⁺离子，并且对Ca²⁺和Ba²⁺离子也具有通透性。当膜片钳微管中为单价阳离子时，单通道电导为37 pS，而当为二价阳离子Ba²⁺和Ca²⁺时，斜率电导分别为16 pS和19 pS。SA通道的开放概率随着负压增加以及去极化而增加。在细胞贴附实验中，低渗休克诱导的细胞肿胀激活了SA通道。文中讨论了SA通道在脑水肿中对脑脊液调节的作用。
Zotero 插件