天然抗半乳糖抗体与α-半乳糖基表位的相互作用：人类异种移植的主要障碍

Interaction of the natural anti-Gal antibody with alpha-galactosyl epitopes: a major obstacle for xenotransplantation in humans.

作者信息

Galili U

机构信息

Dept of Microbiology and Immunology, Medical College of Pennsylvania, Philadelphia 19129.

出版信息

Immunol Today. 1993 Oct;14(10):480-2. doi: 10.1016/0167-5699(93)90261-i.

DOI:10.1016/0167-5699(93)90261-i

PMID:7506033

Abstract

Cells of nonprimate mammals express an abundance of the carbohydrate structure Gal alpha 1-3 Gal beta 1-4 GlcNac-R (termed the alpha-galactosyl epitope). The natural anti-Gal antibody, which interacts specifically with alpha-galactosyl epitopes, is present in high concentrations in all humans. Here, Uri Galili argues that the interaction between anti-Gal in the serum and alpha-galactosyl epitopes on cells of nonprimate grafts may act as an immunological barrier which prevents xenotransplantation.

摘要

非灵长类哺乳动物的细胞表达大量的碳水化合物结构Galα1-3Galβ1-4GlcNac-R（称为α-半乳糖基表位）。天然抗Gal抗体与α-半乳糖基表位特异性相互作用，在所有人类中都以高浓度存在。在此，尤里·加利利认为血清中的抗Gal与非灵长类移植物细胞上的α-半乳糖基表位之间的相互作用可能作为一种免疫屏障，阻止异种移植。