促性腺激素释放激素（GnRH）的脉冲式释放是GT1 GnRH神经元细胞系的固有特性。
Pulsatile release of gonadotrophin releasing hormone (GnRH) is an intrinsic property of GT1 GnRH neuronal cell lines.
作者信息
Weiner R I, Martinez de la Escalera G
机构信息
Reproductive Endocrinology Center, University of California, San Francisco 94143.
出版信息
Hum Reprod. 1993 Nov;8 Suppl 2:13-7. doi: 10.1093/humrep/8.suppl_2.13.
The GT1-1 gonadotrophin releasing hormone (GnRH) cell line releases GnRH in a pulsatile fashion. This finding demonstrates that the generation and synchronization of GnRH pulses is an intrinsic property of GnRH neurons. It appears that propagated action potentials and a Ca(2+)-coupled secretory mechanism are necessary for pulsatile release. The secretion of GnRH from GT1 cells is stimulated by both norepinephrine and dopamine respectively via beta 1-adrenergic and D1-dopaminergic receptors. These findings provide new data for the understanding of the complex neuroendocrine regulation of luteinizing hormone.
GT1-1促性腺激素释放激素（GnRH）细胞系以脉冲方式释放GnRH。这一发现表明，GnRH脉冲的产生和同步是GnRH神经元的固有特性。似乎传播的动作电位和钙偶联分泌机制对于脉冲式释放是必需的。GT1细胞分泌GnRH分别受去甲肾上腺素和多巴胺通过β1-肾上腺素能受体和D1-多巴胺能受体的刺激。这些发现为理解促黄体生成素复杂的神经内分泌调节提供了新的数据。
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