Livett B G, Marley P D
Department of Biochemistry, University of Melbourne, Australia.
J Anat. 1993 Oct;183 ( Pt 2)(Pt 2):277-89.
It has been known for over 70 years that adrenal catecholamine secretion can be modulated or elicited by noncholinergic neurotransmitters and hormones. However, our understanding of the cellular mechanisms by which these agents produce their effects and the physiological conditions under which they act are not well characterised. Here we briefly review the mechanisms by which one such agent (the neuropeptide substance P) modulates the cholinergic secretory response of adrenal chromaffin cells, and another agent (angiotensin II) elicits catecholamine secretion independently of the cholinergic innervation.
70多年来,人们一直知道肾上腺儿茶酚胺的分泌可被非胆碱能神经递质和激素调节或引发。然而,我们对这些物质产生作用的细胞机制以及它们发挥作用的生理条件了解并不充分。在此,我们简要回顾一种物质(神经肽P物质)调节肾上腺嗜铬细胞胆碱能分泌反应的机制,以及另一种物质(血管紧张素II)独立于胆碱能神经支配引发儿茶酚胺分泌的机制。