Hendler N H, Livingston A
Pavlov J Biol Sci. 1978 Jul-Sep;13(3):187-93. doi: 10.1007/BF03001394.
Central nervous system effects have been demonstrated for angiotensin II and suggested for aldosterone. In order to determine whether either of these chemicals naturally crosses the blood-brain barrier, radioactive aldosterone and angiotensin II were introduced via intracardiac injections in rats. Samples of blood, liver, kidney, adrenals, cerebral cortex, and hypothalamus were collected at three, 15, and 60 minutes, frozen, dissolved, and counted. Blood levels for aldosterone and angiotensin II remained constant over 60 minutes. Aldosterone accumulated in the liver, kidney, adrenals and hypothalamus three minutes after injection, and levels diminished over time. Angiotensin II levels peaked in the adrenal, kidney, and liver after three minutes, and in the hypothalamus after 15 minutes. Cerebral cortex levels were lower than hypothalamic levels by 30% for aldosterone and 50% for angiotensin II. This suggests that both drugs may enter the central nervous system and selectively accumulate in the hypothalamus.
已经证实血管紧张素II对中枢神经系统有影响，并且有人提出醛固酮也有此作用。为了确定这两种化学物质是否能自然穿过血脑屏障，通过向大鼠心内注射放射性醛固酮和血管紧张素II进行研究。在3分钟、15分钟和60分钟时采集血液、肝脏、肾脏、肾上腺、大脑皮层和下丘脑的样本，冷冻、溶解并计数。醛固酮和血管紧张素II的血液水平在60分钟内保持恒定。注射后3分钟，醛固酮在肝脏、肾脏、肾上腺和下丘脑积聚，其水平随时间下降。血管紧张素II的水平在3分钟后在肾上腺、肾脏和肝脏中达到峰值，在15分钟后在下丘脑中达到峰值。醛固酮在大脑皮层中的水平比下丘脑低30%，血管紧张素II低50%。这表明这两种药物都可能进入中枢神经系统并选择性地在下丘脑积聚。
