内皮素ETA受体拮抗剂BQ-123可使自发性高血压大鼠主动脉对钙离子通道激活剂的反应恢复正常。
The endothelin ETA receptor antagonist, BQ-123, normalizes the response of SHR aorta to Ca2+ channel activator.
作者信息
Morel N, Godfraind T
机构信息
Laboratoire de Pharmacologie, Université Catholique de Louvain, Brussels, Belgium.
出版信息
Eur J Pharmacol. 1994 Feb 3;252(2):R3-4. doi: 10.1016/0014-2999(94)90603-3.
Hypertension is associated with a hypersensitive response to the Ca2+ channel activator, Bay K 8644. We investigated the effect of the endothelin ETA receptor antagonist, BQ-123, on the contractions induced by Bay K 8644 in aorta from spontaneously hypertensive (SHR) and normotensive Wistar Kyoto (WKY) rats. BQ-123 (1 microM) decreased the sensitivity to Bay K 8644 of aorta of SHR down to that of WKY. This observation is consistent with a role for endothelin in hypertension.
高血压与对钙离子通道激活剂Bay K 8644的超敏反应有关。我们研究了内皮素ETA受体拮抗剂BQ-123对自发性高血压（SHR）大鼠和正常血压的Wistar Kyoto（WKY）大鼠主动脉中由Bay K 8644诱导的收缩的影响。BQ-123（1微摩尔）将SHR主动脉对Bay K 8644的敏感性降低至WKY大鼠的水平。这一观察结果与内皮素在高血压中的作用一致。
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