大鼠淋巴结和脾脏中α2-肾上腺素能受体的鉴定：一项放射自显影研究。
Identification of alpha 2-adrenoceptors in rat lymph nodes and spleen: an autoradiographic study.
作者信息
Fernández-López A, Pazos A
机构信息
Department of Cellular Biology and Anatomy, Faculty of Biology, University of León, Santander, Spain.
出版信息
Eur J Pharmacol. 1994 Feb 11;252(3):333-6. doi: 10.1016/0014-2999(94)90182-1.
The anatomical localization and pharmacological characteristics of alpha 2-adrenoceptors were studied in rat lymphoid tissues by quantitative autoradiography with [3H]bromoxidine as a ligand. In lymph nodes, a significant density of these receptors was found in the capsule, interfollicular cortex and medullary cords, while only very low densities were observed in the paracortex and germinal centres. In the spleen, these receptors appeared to be mainly distributed in the marginal zone of white pulp as well as in the red pulp. These results suggest a role for alpha 2-adrenoceptors in the interaction between nervous and immune systems.
以[³H]溴昔定作为配体，通过定量放射自显影术研究了大鼠淋巴组织中α₂ - 肾上腺素能受体的解剖定位和药理学特性。在淋巴结中，这些受体在被膜、滤泡间皮质和髓索中有显著密度，而在副皮质区和生发中心仅观察到极低密度。在脾脏中，这些受体似乎主要分布在白髓边缘区以及红髓。这些结果提示α₂ - 肾上腺素能受体在神经和免疫系统相互作用中起作用。
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