Grossmann M, Trautmann M E, Poertl S, Hoermann R, Berger P, Arnold R, Mann K
Department of Medicine II, Klinikum Grosshadern, University of Munich, Germany.
Eur J Clin Invest. 1994 Feb;24(2):131-6. doi: 10.1111/j.1365-2362.1994.tb00978.x.
In the serum of patients with malignant endocrine gastroenteropancreatic (GEP) tumours, both alpha-subunit (alpha-SU), common to all glycoprotein hormones, as well as free beta-subunit of human chorionic gonadotropin (hCG-beta) have been reported to be elevated in a substantial fraction. Both have been discussed as markers of malignancy in these neoplasms. In the present study we evaluated the diagnostic significance of alpha-SU and hCG-beta as serum markers in patients with malignant endocrine gastroenteropancreatic tumours. The study group consisted of 52 patients with endocrine GEP-malignancies (24 nonfunctioning, 23 carcinoid syndromes, four gastrinoma, one glucagonoma), located in the small intestine (n = 29), pancreas (n = 17), colon or rectum (n = 3), retroperitoneum (n = 2) and stomach (n = 1). alpha-SU and hCG-beta immunoreactivity was also assessed in the serum of patients with benign GEP-tumors (five insulinoma, and three gastrinoma). Concentrations of alpha-SU and hCG-beta were determined using two highly sensitive and specific immunoradiometric assays employing two monoclonal antibodies each. In 19 of 52 patients (37%), either alpha-SU (n = 9), hCG-beta (n = 7) or both subunits (n = 3) were elevated. In the subgroup of 24 patients with nonfunctioning GEP-tumours, increased concentrations of either alpha-SU (n = 6) or hCG-beta(n = 3) or both subunits (n = 1) were found in 10 of 24 patients (42%). In four of 23 patients with carcinoid syndrome (17%), either alpha-SU (n = 2), hCG-beta(n = 1) or both subunits (n = 1) were above the normal range.(ABSTRACT TRUNCATED AT 250 WORDS)
在恶性内分泌胃肠胰腺（GEP）肿瘤患者的血清中，据报道所有糖蛋白激素共有的α亚基（α-SU）以及人绒毛膜促性腺激素游离β亚基（hCG-β）在很大一部分患者中升高。二者都被讨论作为这些肿瘤恶性程度的标志物。在本研究中，我们评估了α-SU和hCG-β作为恶性内分泌胃肠胰腺肿瘤患者血清标志物的诊断意义。研究组由52例内分泌GEP恶性肿瘤患者组成（24例无功能性肿瘤、23例类癌综合征、4例胃泌素瘤、1例胰高血糖素瘤），肿瘤位于小肠（n = 29）、胰腺（n = 17）、结肠或直肠（n = 3）、腹膜后（n = 2）和胃（n = 1）。还对良性GEP肿瘤患者（5例胰岛素瘤和3例胃泌素瘤）的血清进行了α-SU和hCG-β免疫反应性评估。使用两种高灵敏度和特异性的免疫放射分析方法分别测定α-SU和hCG-β的浓度，并各自使用两种单克隆抗体。52例患者中有19例（37%）α-SU（n = 9）、hCG-β（n = 7）或两个亚基（n = 3）升高。在24例无功能性GEP肿瘤患者亚组中，24例患者中有10例（42%）发现α-SU（n = 6）或hCG-β（n = 3）或两个亚基（n = 1）浓度升高。23例类癌综合征患者中有4例（17%）α-SU（n = 2）、hCG-β（n = 1）或两个亚基（n = 1）超出正常范围。（摘要截断于250字）
