维拉帕米和伊洛前列素（ZK 36374）对肠系膜缺血再灌注损伤后内皮素释放的影响。
Effect of verapamil and iloprost (ZK 36374) on endothelin release after mesenteric ischemia-reperfusion injury.
作者信息
Yeğen C, Aktan A O, Büyükgebiz O, Haklar G, Yalçin A S, Yalin R, Ercan S
机构信息
Marmara University School of Medicine, Istanbul, Turkey.
出版信息
Eur Surg Res. 1994;26(2):69-75. doi: 10.1159/000129320.
In this experimental study we studied the effect of verapamil and iloprost on endothelin release in ischemia/reperfusion (IR) injury of the rat intestine. Endothelin levels in the portal blood and malondialdehyde (MDA), PGE2, and LTC4 levels in the intestinal tissue were determined. The MDA levels increased in the control group and this increase was reversed with iloprost, verapamil and both. The change in the LTC4 levels was insignificant between the groups. Iloprost reduced PGE2 and endothelin release, but verapamil was not as effective and no synergistic effect was encountered. The increased PGE2/LTC4 ratio was also reversed in the experimental groups, verapamil being less effective. Endothelin release seems to be related to both PGE2 levels and the PGE2/LTC4 ratio after mesenteric IR injury.
在本实验研究中，我们研究了维拉帕米和伊洛前列素对大鼠肠缺血/再灌注（IR）损伤中内皮素释放的影响。测定了门静脉血中的内皮素水平以及肠组织中的丙二醛（MDA）、前列腺素E2（PGE2）和白三烯C4（LTC4）水平。对照组中MDA水平升高，而伊洛前列素、维拉帕米以及二者联合使用均可逆转这一升高。各组间LTC4水平变化不显著。伊洛前列素可降低PGE2和内皮素的释放，但维拉帕米效果不佳，且未观察到协同作用。实验组中升高的PGE2/LTC4比值也有所逆转，维拉帕米的效果较差。肠系膜IR损伤后，内皮素释放似乎与PGE2水平及PGE2/LTC4比值均有关。
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