No TP53 mutations in neuroblastomas detected by PCR-SSCP analysis.
作者信息
Castresana J S, Bello M J, Rey J A, Nebreda P, Queizán A, García-Miguel P, Pestaña A
机构信息
Instituto de Investigaciones Biomédicas, C.S.I.C., Madrid, Spain.
出版信息
Genes Chromosomes Cancer. 1994 Jun;10(2):136-8. doi: 10.1002/gcc.2870100209.
PMID:7520267
Abstract
We have analysed 29 neuroblastomas for TP53 mutations in exons 5 to 8 by means of the polymerase chain reaction in combination with the single-strand conformation polymorphism technique. We could not detect any mutation. These results indicate that, in contrast to the majority of tumors so far studied, TP53 mutations do not seem to be important for the development of neuroblastomas.
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