蛋白质中氨基酸的组成频率与遗传密码。

Compositional frequencies of amino acids in the proteins and the genetic code.

作者信息

Siemion I Z

机构信息

Institute of Chemistry, Wrocław University, Poland.

出版信息

Biosystems. 1994;32(3):163-70. doi: 10.1016/0303-2647(94)90039-6.

DOI:10.1016/0303-2647(94)90039-6

PMID:7522604

Abstract

It was found that amino acid compositional frequencies in proteins demonstrate a pseudosymmetry pattern in respect of the genetic code arrangement as we discussed in earlier papers (Siemion and Stefanowicz, 1992a, BioSystems, 27, 77-84; Siemion and Stefanowicz, 1992b, Bull. Pol. Acad. Sci., Chem. 40, 11-20; Siemion, 1994, BioSystems, 32, 25-35). The type of pseudosymmetry observed is very similar to that found in the changes of Chou-Fasman P alpha conformational parameters within the genetic code arrangement. It is also shown that the compositional frequencies of amino acids belonging to the 'G' and 'C' families of codons (excluding UCN Ser codons) change linearly with the sequence of the one-step mutations expected by our arrangement of proper codons.

摘要

正如我们在早期论文中所讨论的（Siemion和Stefanowicz，1992a，《生物系统》，27，77 - 84；Siemion和Stefanowicz，1992b，《波兰科学院通报，化学》，40，11 - 20；Siemion，1994，《生物系统》，32，25 - 35），研究发现蛋白质中的氨基酸组成频率在遗传密码排列方面呈现出一种假对称模式。所观察到的假对称类型与在遗传密码排列中周 - 法斯曼Pα构象参数变化中发现的非常相似。还表明，属于密码子“G”和“C”家族的氨基酸（不包括UCN丝氨酸密码子）的组成频率随着我们正确密码子排列所预期的一步突变序列呈线性变化。