Suppr超能文献

用氟哌啶醇或溴隐亭进行短期治疗不会改变黑质中单胺囊泡转运体的密度。

Short-term treatments with haloperidol or bromocriptine do not alter the density of the monoamine vesicular transporter in the substantia nigra.

作者信息

Naudon L, Leroux-Nicollet I, Costentin J

机构信息

Unité de Neuropsychopharmacologie Expérimentale, Unité Associée 1170 du CNRS, Faculté de Médecine et Pharmacie, Université de Rouen, Saint Etienne du Rouvray, France.

出版信息

Neurosci Lett. 1994 May 23;173(1-2):1-4. doi: 10.1016/0304-3940(94)90136-8.

Abstract

[3H]dihydrotetrabenazine ([3H]TBZOH) was used to label the monoamine vesicular transporter in the rat substantia nigra. An accumulation of neuronal vesicles in the substantia nigra pars compacta was observed after blockade of the fast axonal transport by a microinjection of colchicine (10 micrograms/2 microliters) into the medial forebrain bundle. This accumulation was measured after sustained 2-day pharmacological modifications of the central dopaminergic transmission. It was not modified after s.c. administration of either the direct dopamine (DA) receptor agonist bromocriptine (four injections of 4 or 6 mg/kg) or the DA receptor antagonist haloperidol (four injections of 0.5-1-1.5-2 mg/kg). Thus, it appears that these pharmacological modifications, imposed to the activity of the nigro-striatal dopaminergic system during 2 days, have no consequence on the rate of synthesis of its vesicles.

摘要

[3H]二氢丁苯那嗪([3H]TBZOH)用于标记大鼠黑质中的单胺囊泡转运体。通过向内侧前脑束微量注射秋水仙碱(10微克/2微升)阻断快速轴突运输后,观察到黑质致密部神经元囊泡的积累。在对中枢多巴胺能传递进行持续2天的药理学修饰后,对这种积累进行了测量。皮下注射直接多巴胺(DA)受体激动剂溴隐亭(4次注射,每次4或6毫克/千克)或DA受体拮抗剂氟哌啶醇(4次注射,每次0.5 - 1 - 1.5 - 2毫克/千克)后,这种积累没有改变。因此,似乎在2天内对黑质 - 纹状体多巴胺能系统的活性进行的这些药理学修饰,对其囊泡的合成速率没有影响。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验