Activation sequence of discrete brain areas during cognitive processes: results from magnetic field tomography.

Magnetic field tomography is a technique for extracting 3-dimensional estimates of current density in the brain, from non-contact, non-invasive measurements of the magnetic field generated by the brain. It allows visualisation of both cortical and subcortical focal activation patterns at millisecond intervals, and the relative time difference between active cortical areas. We have used this technique to study the activation history of discrete brain regions associated with the preparation for, initiation and inhibition of movement, and movement itself in a CNV paradigm. The strongest focal activities are found within well defined cortical regions, namely the auditory (A1), sensorimotor (SM1), medial parietal area (MPA) and anterior supplementary motor area (SMA). For the movement condition, activation history differs for the warning stimulus and the stimulus initiating movement.