免疫牛对双芽巴贝斯虫顶体相关蛋白1表面暴露且对中和敏感的表位的抗体反应。
Antibody response to a Babesia bigemina rhoptry-associated protein 1 surface-exposed and neutralization-sensitive epitope in immune cattle.
作者信息
Ushe T C, Palmer G H, Sotomayor L, Figueroa J V, Buening G M, Perryman L E, McElwain T F
机构信息
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040.
出版信息
Infect Immun. 1994 Dec;62(12):5698-701. doi: 10.1128/iai.62.12.5698-5701.1994.
Abstract
Protective immunity against Babesia bigemina is hypothesized to involve antibodies directed against merozoite surface-exposed epitopes. Levels of antibody against a rhoptry-associated protein 1 (RAP-1) B-lymphocyte epitope, defined by surface-reactive and inhibitory monoclonal antibodies, in immune cattle sera were determined. All cattle produced antibodies to the epitope; however, there was limited correlation between immune protection induced by infection or RAP-1 immunization and the level of antibody to the neutralization-sensitive B-lymphocyte epitope examined.
摘要
据推测，针对双芽巴贝斯虫的保护性免疫涉及针对裂殖子表面暴露表位的抗体。测定了免疫牛血清中针对由表面反应性和抑制性单克隆抗体所定义的一种棒状体相关蛋白1（RAP-1）B淋巴细胞表位的抗体水平。所有牛都产生了针对该表位的抗体；然而，感染或RAP-1免疫诱导的免疫保护与所检测的对中和敏感的B淋巴细胞表位的抗体水平之间的相关性有限。
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本文引用的文献
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Immunogenic B-cell epitopes of Babesia bovis rhoptry-associated protein 1 are distinct from sequences conserved between species.牛巴贝斯虫棒状体相关蛋白1的免疫原性B细胞表位与种间保守序列不同。
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Antibodies define multiple proteins with epitopes exposed on the surface of live Babesia bigemina merozoites.抗体可识别多种蛋白质，这些蛋白质的表位暴露于活的双芽巴贝斯虫裂殖子表面。
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