Novel assay for the influenza virus M2 channel activity.
作者信息
Giffin K, Rader R K, Marino M H, Forgey R W
机构信息
Department of Protein Biochemistry, Searle Research and Development, St. Louis, MO.
出版信息
FEBS Lett. 1995 Jan 9;357(3):269-74. doi: 10.1016/0014-5793(94)01369-c.
PMID:7530665
Abstract
The influenza A M2 ion channel was expressed and activity characterized in Xenopus oocytes. Based on the activation properties of the channels, a high throughput, non-electrophysiological screening assay was developed in order to identify novel inhibitors of the channel. This will facilitate discovery of novel agents to treat influenza viral infections.
摘要
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