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[破伤风毒素与有机磷酸酯在胆碱酯酶阻断方面可能存在的相互干扰]

[Possible interference between tetanus toxin and organo-phosphorus esters in blocking of cholinesterase].

作者信息

Leonardi G, Gazzei G, Zanierato G

出版信息

Ann Sclavo. 1978 Sep-Oct;20(5):664-70.

PMID:753135
Abstract

As tetanus toxin results inactivated when mixed with mammals brain homogenate (Wassermann-Takaki phenomenon), the same may be observed for the organophosphorus compounds. When the brain homogenates are mixed before with one of both poisons and subsequently, after incubation, with the other, this one keeps its typical toxic activity. This behavior seems to be interpreted as the result from the linkage between the true cholinesterase and one toxic (Wassermann-Takaki phenomenon both for the tetanus toxin and the "parathion"), with the following interference for the second toxic, when added, at the enzymatic level, so that the second toxic remains free.

摘要

由于破伤风毒素与哺乳动物脑匀浆混合时会失活(瓦塞尔曼-高木现象),有机磷化合物也可能出现同样情况。当脑匀浆先与两种毒物之一混合,孵育后再与另一种毒物混合时,后一种毒物仍保持其典型的毒性活性。这种行为似乎可以解释为真正的胆碱酯酶与一种毒物(破伤风毒素和“对硫磷”均存在瓦塞尔曼-高木现象)之间发生了结合,当加入第二种毒物时,在酶水平上产生了干扰,从而使第二种毒物保持游离状态。

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