Müller J G, Czub S, Rethwilm A, Müller-Hermelink H K
Pathologisches Institut, Universität Würzburg.
Verh Dtsch Ges Pathol. 1994;78:310-3.
22 juvenile rhesus macaques were infected i.v. with SIVmac and killed at defined timepoints after infection. Productively infected cells were detected by RNA in situ hybridization in the paraffin material. Their number was correlated with the pathology of lymph nodes, thymus, extranodal lymphatic parenchyma and other organs. In the first weeks all lymphatic tissues and compartments got infected, as well as the brain, the bone marrow and other organs. The high virus replication during this first phase disappeared with the onset of the seroconversion and remained low during all stages of atrophy of the lymphatic parenchyma. The atrophy of the lymphatic parenchyma and its microenvironment was not correlated with virus replication. This may implicate that a virostatic therapy might be more successful in the first weeks of infection.
22只幼年恒河猴经静脉注射感染了猴免疫缺陷病毒（SIVmac），并在感染后的特定时间点处死。通过RNA原位杂交在石蜡材料中检测到有病毒复制的感染细胞。其数量与淋巴结、胸腺、结外淋巴实质及其他器官的病理变化相关。在最初几周，所有淋巴组织和腔室以及脑、骨髓和其他器官均被感染。随着血清转化的开始，第一阶段的高病毒复制消失，并且在淋巴实质萎缩的所有阶段均保持在低水平。淋巴实质及其微环境的萎缩与病毒复制无关。这可能意味着在感染的最初几周进行病毒抑制疗法可能会更成功。
