Sunder G S, Parsons K F, Gibbon N O
Br J Urol. 1978 May;50(3):190-9. doi: 10.1111/j.1464-410x.1978.tb02801.x.
Urethral pressure profiles were recorded in a series of patients with traumatic lesions of the spinal cord producing vesico-urethral dysfunction. Patients were classified into groups depending upon the relationship of the lesion to the sympathetic outflow to the bladder and urethra from the spinal cord. Using alpha-adrenergic blocking agents, the smooth muscle contribution to the maximum urethral pressure was ascertained in each group and differences in both the configuration of the profile, and the smooth muscle component, were found. Increases in the maximum urethral pressure in response to a change in posture were also investigated, and the extent of the increase found to vary according to the level of the spinal lesion in respect of the sympathetic outflow, and with the integrity of the sacral cholinergic reflex arcs. The hypothesis that these changes may be due to urethral "decentralisation supersensitivity" from alterations in circulating catecholamine levels is suggested.
对一系列因脊髓创伤性损伤导致膀胱尿道功能障碍的患者记录了尿道压力曲线。根据脊髓损伤与膀胱和尿道交感神经传出的关系，将患者分为不同组。使用α-肾上腺素能阻滞剂，确定每组中平滑肌对最大尿道压力的贡献，并发现压力曲线形态和平滑肌成分均存在差异。还研究了因姿势改变导致的最大尿道压力增加情况，发现增加程度因脊髓损伤在交感神经传出方面的水平以及骶部胆碱能反射弧的完整性而异。有人提出假说，认为这些变化可能是由于循环中儿茶酚胺水平改变导致尿道“去神经超敏反应”所致。
