rd小鼠视网膜光感受器变性后谷氨酸受体亚基表达的变化。

Changes in expression of glutamate receptor subunits following photoreceptor degeneration in the rd mouse retina.

作者信息

Duvoisin R M, Zhang C, Hamassaki-Britto D E, Britto L R

机构信息

Margaret M. Dyson Vision Research Institute, Department of Ophthalmology, Cornell University Medical College, New York, NY 10021, USA.

出版信息

Neurosci Lett. 1995 Jan 2;183(1-2):83-6. doi: 10.1016/0304-3940(94)11120-8.

DOI:10.1016/0304-3940(94)11120-8

PMID:7538211

Abstract

The effects of photoreceptor cell degeneration on the expression of nine alpha-amino-3-hydroxy-5-methyl-isoxasole-4-propionate (AMPA)/kainate glutamate receptor subunit genes were investigated in the rd mouse retina by in situ hybridization. All known AMPA/kainate receptor subunits were found to be expressed in normal mouse retina. Following retinal degeneration, the expression of KA-1 was reduced, that of the GluR7 subunit was greatly increased, and that of the other seven subunits were not significantly affected.

摘要

通过原位杂交技术，在rd小鼠视网膜中研究了光感受器细胞变性对9种α-氨基-3-羟基-5-甲基异恶唑-4-丙酸（AMPA）/海人藻酸谷氨酸受体亚基基因表达的影响。结果发现，所有已知的AMPA/海人藻酸受体亚基在正常小鼠视网膜中均有表达。视网膜变性后，KA-1的表达降低，GluR7亚基的表达大幅增加，而其他7个亚基的表达未受显著影响。