Ivanov V A, Il'in Iu V
Mol Biol (Mosk). 1995 Mar-Apr;29(2):258-80.
Elements with open-reading translation frames homologous to retroviral RNA-dependent DNA polymerases (reverse transcriptases) were found in eukaryotic cell genomes. Expression of endogenous reverse transcriptases in prokaryotic and eukaryotic cells is confirmed directly and indirectly. Evolution and function of reverse transcriptases are analyzed, and their phylogenetic and ontogenetic role is evaluated.
在真核细胞基因组中发现了与逆转录病毒RNA依赖性DNA聚合酶(逆转录酶)具有开放阅读翻译框架同源性的元件。原核细胞和真核细胞中内源性逆转录酶的表达已得到直接和间接证实。对逆转录酶的进化和功能进行了分析,并评估了它们在系统发育和个体发育中的作用。