Poupon M F
URA 620 CNRS, service de biologie, institut Curie, Paris, France.
Bull Cancer. 1995;82 Suppl 2:93s-100s.
Metastases result from the implantation of tumor cells into various organs, distant from the primary tumor. Among primary tumor cells, a small number undergo genetic events determining metastatic function acquisition. The metastatic function comprises the lack of homotypic intercellular connections, due to proteolytic enzyme effects and/or lack of adhesion molecule synthesis, stimulation of peri- and intratumoral angiogenesis, motility adhesion molecule synthesis, stimulation of peri- and intratumoral angiogenesis, motility and invasiveness, adhesiveness to acellular substrates or heterotypic cells, resistance to immune defenses, alteration of growth factor receptivity, and even growth autonomy. Formation of metastatic foci needs the establishment of an ecosystem born from the contribution of both host and tumor and in which respective cells interact.
转移是由肿瘤细胞植入到远离原发肿瘤的各个器官所导致的。在原发肿瘤细胞中，少数细胞会经历决定获得转移功能的基因事件。转移功能包括由于蛋白水解酶的作用和/或缺乏黏附分子合成而导致的同型细胞间连接缺失、肿瘤周围和肿瘤内血管生成的刺激、运动黏附分子的合成、肿瘤周围和肿瘤内血管生成的刺激、运动性和侵袭性、对无细胞底物或异型细胞的黏附性、对免疫防御的抵抗、生长因子受体敏感性的改变，甚至生长自主性。转移灶的形成需要建立一个由宿主和肿瘤共同作用产生的生态系统，其中各自的细胞相互作用。
