Guidolin R, Zelante F, de Lorenzo J L, Villarroel M S
Arq Inst Biol (Sao Paulo). 1978 Apr-Jun;45(2):83-99.
The authors verified the following: The FLURY HEP vaccine, with modified virus, confers a higher level of protection when applied by intracerebral route in laboratory animals. With an equal number of viral particles of FLURY HEP modified virus and fixed virus (FUENZALIDA type vaccine), inoculated intracerebrally and intramusculary, a better protection was obtained with the first kind of vaccine, specially by intracerebral route. These conditions suggest the possibility of replication of modified HEP virus in the cells of the central nervous system. The results show that the concentration of neutralizing antibodies in the serum is not the only responsable for protection, but suggests the possibility of factors or of cellular immunity acting in the animal's protection against rabies.
经改良病毒的弗吕里HEP疫苗，通过脑内途径应用于实验动物时可提供更高水平的保护。将等量的弗吕里HEP改良病毒和固定病毒（富恩扎利达型疫苗）的病毒颗粒经脑内和肌肉内接种后，第一种疫苗能提供更好的保护，特别是通过脑内途径。这些情况表明改良的HEP病毒有可能在中枢神经系统细胞中复制。结果表明，血清中中和抗体的浓度并非保护的唯一原因，而是提示存在某些因素或细胞免疫在动物抵抗狂犬病中发挥作用的可能性。
