真性红细胞增多症中的循环造血祖细胞：羟基脲的体内效应
Circulating hematopoietic progenitor cells in polycythemia vera: the in vivo effect of hydroxyurea.
作者信息
Castello G, Lerza R, Cerruti A, Cavallini D, Bogliolo G, Pannacciulli I
机构信息
Department of Internal Medicine, University of Genoa, Italy.
出版信息
Ann Hematol. 1995 Sep;71(3):119-21. doi: 10.1007/BF01702646.
The in vivo effects of hydroxyurea (HU) on circulating erythroid (BFU-E) and granulocyte-macrophage progenitors (CFU-GM) in patients with polycythemia vera (PV) have been evaluated. HU induced a strong decrease of both BFU-E and CFU-GM in the first month of treatment. During the following 4 months of treatment the level of circulating progenitors remained at very low values, until the end of the period of observation. HU activity involved both erythroid and myeloid committed progenitors and both erythropoietin-stimulated (normal) and endogenous (derived from the abnormal PV clone) BFU-E.
已经评估了羟基脲（HU）对真性红细胞增多症（PV）患者循环中的红系祖细胞（BFU-E）和粒-巨噬细胞祖细胞（CFU-GM）的体内作用。在治疗的第一个月，HU使BFU-E和CFU-GM均显著减少。在接下来的4个月治疗期间，循环祖细胞水平一直维持在非常低的值，直至观察期结束。HU的作用涉及红系和髓系定向祖细胞，以及促红细胞生成素刺激的（正常）和内源性的（源自异常PV克隆）BFU-E。
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