通过同源建模提出的凝血因子VIII A结构域的结构
Proposed structure of the A domains of factor VIII by homology modelling.
作者信息
Pan Y, DeFay T, Gitschier J, Cohen F E
出版信息
Nat Struct Biol. 1995 Sep;2(9):740-4. doi: 10.1038/nsb0995-740.
PMID:7552743
Abstract
We have predicted a structure for the three A domains of blood coagulation factor VIII by virtue of their homology to blue copper-binding proteins. This structure, consisting of six beta-barrels, is arranged in a triangular configuration with a single type II copper-binding site linking the A1 and A3 domains.
摘要
我们借助凝血因子VIII的三个A结构域与蓝色铜结合蛋白的同源性预测了其结构。该结构由六个β桶组成，呈三角形排列，有一个单一的II型铜结合位点连接A1和A3结构域。
Zotero 插件