Hagen E C, de Keizer R J, Andrassy K, van Boven W P, Bruijn J A, van Es L A, van der Woude F J
Department of Nephrology, University Hospital Leiden, The Netherlands.
Clin Nephrol. 1995 Jun;43(6):351-9.
The purpose of this study was to evaluate the effect of treatment with anti-thymocyte globulin in patients with Wegener's granulomatosis, untreatable with cyclophosphamide and steroids.
Five patients with active Wegener's granulomatosis, either not responsive to standard therapy, or who could not tolerate alkylating agents received a single course of rabbit anti-thymocyte globulin (ATG).
Four patients showed a favourable response to treatment with partial or complete remission of disease activity, during a follow-up period of five to twelve months. One patient had progressive retroorbital granuloma, which resulted in enucleation of the eye. Side effects of the ATG treatment were mild with chills and fever during the first infusion, and development of serum sickness in two patients. Two other patients had labial herpes simplex shortly after the start of treatment, no other infectious complications were seen.
We conclude that ATG treatment seems to be an effective treatment for patients with severe Wegener's granulomatosis.
本研究的目的是评估抗胸腺细胞球蛋白对韦格纳肉芽肿患者的治疗效果，这些患者无法用环磷酰胺和类固醇进行治疗。
五例活动性韦格纳肉芽肿患者，要么对标准治疗无反应，要么不能耐受烷化剂，接受了一个疗程的兔抗胸腺细胞球蛋白（ATG）治疗。
在五至十二个月的随访期内，四名患者对治疗表现出良好反应，疾病活动部分或完全缓解。一名患者出现进行性眶后肉芽肿，导致眼球摘除。ATG治疗的副作用较轻，首次输注时出现寒战和发热，两名患者出现血清病。另外两名患者在治疗开始后不久出现唇单纯疱疹，未见其他感染并发症。
我们得出结论，ATG治疗似乎是重度韦格纳肉芽肿患者的有效治疗方法。
