Adkins M S, Amalfitano D, Harnum N A, Laub G W, McGrath L B
Department of Thoracic and Cardiovascular Surgery, Deborah Heart and Lung Center, Browns Mills, NJ, USA.
Chest. 1995 Oct;108(4):927-31. doi: 10.1378/chest.108.4.927.
From January 1982 to October 1991, 42 consecutive patients 80 years of age and older underwent a combined cardiac procedure with coronary revascularization and valve repair or replacement. There were 20 women and 22 men. Mean age at operation was 82.8 years (range, 80 to 89.7 years). Twenty-seven patients (64%) were in New York Heart Association (NYHA) functional class III or IV preoperatively. Six patients (14.3%) had undergone previous cardiac procedures. There were six hospital deaths (14.3%). The only significant preoperative risk factor identified for the event hospital death was aortic insufficiency (p = 0.005). The 36 hospital survivors were followed up at a mean of 21.1 months after hospital discharge. There were nine (21%) late deaths occurring at a mean of 21.3 months postoperatively: two from acute myocardial infarctions and seven from chronic heart failure. Survival analysis indicated that higher preoperative NYHA class (p = 0.0003), hypertension (p = 0.015), hypercholesterolemia (p = 0.03), and elevated left atrial/left ventricular gradient (p = 0.04) were incremental risk factors for overall mortality. The actuarial survival at 40 months was 51.9%, with no significant difference as compared with an age-, sex-, and race-matched population. Of the 27 late survivors, 26 were in NYHA class I or II. We conclude that octogenarians may undergo complex cardiac surgical procedures with an expectation of an acceptable mortality rate and significant improvement in their functional status. These results must be taken into consideration in light of reported strategies to ameliorate health-care costs by limiting availability of complex medical care to the elderly.
1982年1月至1991年10月,42例连续的80岁及以上患者接受了冠状动脉血运重建与瓣膜修复或置换联合心脏手术。其中女性20例,男性22例。手术时的平均年龄为82.8岁(范围80至89.7岁)。27例患者(64%)术前纽约心脏协会(NYHA)心功能分级为III或IV级。6例患者(14.3%)曾接受过心脏手术。有6例患者院内死亡(14.3%)。确定的唯一与院内死亡事件相关的术前显著危险因素是主动脉瓣关闭不全(p = 0.005)。36例院内幸存者在出院后平均随访21.1个月。有9例(21%)晚期死亡,平均发生在术后21.3个月:2例死于急性心肌梗死,7例死于慢性心力衰竭。生存分析表明,术前较高的NYHA分级(p = 0.0003)、高血压(p = 0.015)、高胆固醇血症(p = 0.03)以及左心房/左心室压力阶差升高(p = 0.04)是总体死亡率的递增危险因素。40个月时的精算生存率为51.9%,与年龄、性别和种族匹配的人群相比无显著差异。27例晚期幸存者中,26例NYHA分级为I或II级。我们得出结论,八旬老人可以接受复杂的心脏外科手术,预期死亡率可接受,且功能状态能得到显著改善。鉴于有报道称通过限制老年人获得复杂医疗服务来改善医疗保健成本的策略,必须考虑这些结果。