Shaker（Kv1）和Shaw（Kv3）亚家族的异源多聚体电压依赖性钾通道中存在缓慢失活现象。
Slow inactivation conserved in heteromultimeric voltage-dependent K+ channels between Shaker (Kv1) and Shaw (Kv3) subfamilies.
作者信息
Shahidullah M, Hoshi N, Yokoyama S, Kawamura T, Higashida H
机构信息
Department of Biophysics, Kanazawa University School of Medicine, Japan.
出版信息
FEBS Lett. 1995 Sep 11;371(3):307-10. doi: 10.1016/0014-5793(95)00928-3.
Single K+ channels were recorded under the cell-attached mode in Xenopus oocytes injected with an equal amount of mRNAs coding for NGK1 (Kv1.2) and NGK2 (Kv3.1a) voltage-dependent K+ channels. A new class of channels of 20 pS in conductance with three degrees of inactivation was observed. The results suggest that voltage-dependent NGK1 Shaker and NGK2 Shaw K+ channels, from different subfamilies, assemble to form heteromultimeric K+ channels in Xenopus oocytes and show characteristics inherited from two parental channels.
在爪蟾卵母细胞中，采用细胞贴附模式记录单个钾离子通道，这些卵母细胞被注射了等量的编码电压依赖性钾离子通道NGK1（Kv1.2）和NGK2（Kv3.1a）的信使核糖核酸。观察到一类新的通道，其电导为20皮安，具有三种失活程度。结果表明，来自不同亚家族的电压依赖性NGK1（Shaker型）和NGK2（Shaw型）钾离子通道在爪蟾卵母细胞中组装形成异源多聚体钾离子通道，并表现出来自两个亲本通道的特性。
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