核仁组织区：上尿路尿路上皮癌的一个新的预后因素。
Nucleolar organizer regions: a new prognostic factor for upper tract urothelial cancer.
作者信息
Jinza S, Iki M, Noguchi S, Shuin T, Kubota Y, Takano Y, Masuda M
机构信息
Department of Urology, Yokohama City University School of Medicine, Kanagawa-ken, Japan.
出版信息
J Urol. 1995 Nov;154(5):1688-92. doi: 10.1016/s0022-5347(01)66751-x.
PURPOSE
The prognostic significance of argyrophilic staining in the nucleolar organizer regions was studied in 63 patients with primary urothelial tumors of the renal pelvis and ureter.
MATERIALS AND METHODS
Silver staining of paraffin embedded sections was performed using a 1-step technique.
RESULTS
The prognosis for patients with a mean number of argyrophilic nucleolar organizer region proteins per nucleus (argyrophilic nucleolar organizer region score) of 8 or greater was significantly worse than that for patients with a score of less than 8 (P <0.001).
CONCLUSIONS
Argyrophilic nucleolar organizer region score is a new prognostic factor in primary urothelial tumors of the renal pelvis and ureter, and it is particularly useful for patients with invasive tumors.
目的
研究63例肾盂和输尿管原发性尿路上皮肿瘤患者核仁组织区嗜银染色的预后意义。
材料与方法
采用一步法对石蜡包埋切片进行银染色。
结果
每个细胞核中嗜银核仁组织区蛋白平均数量（嗜银核仁组织区评分）为8或更高的患者预后明显比评分为8以下的患者差（P<0.001）。
结论
嗜银核仁组织区评分是肾盂和输尿管原发性尿路上皮肿瘤的一个新的预后因素，对浸润性肿瘤患者尤为有用。
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