Tamiya S, Matsuoka M, Takemoto S, Shimizu K, Yamaguchi K, Mita S, Uchino M, Ando M, Miyaguni T, Kuniyoshi K
Second Department of Internal Medicine, Kumamoto University School of Medicine, Japan.
Leukemia. 1995 Oct;9(10):1768-70.
Adult T cell leukemia (ATL) is the T cell malignancy caused by human T lymphotropic virus type I (HTLV-I), and HTLV-I is also the causative agent of HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Although HTLV-I causes both diseases, concomitant occurrence is reported to be rare. This paper describes two cases of HAM/TSP that developed into lymphoma-type ATL after the onset of HAM/TSP. In one case, the same HTLV-I infected clone could be detected by polymerase chain reaction in peripheral blood obtained when the patient was diagnosed as HAM/TSP. This finding showed that the HTLV-I clone already existed at the stage of HAM/TSP. Since frequent detection of clonal proliferation of HTLV-I infected cells has been reported previously in patients with HAM/TSP, careful follow-up is needed for patients with HAM/TSP.
成人T细胞白血病（ATL）是由I型人类嗜T淋巴细胞病毒（HTLV-I）引起的T细胞恶性肿瘤，HTLV-I也是HTLV-I相关脊髓病/热带痉挛性截瘫（HAM/TSP）的病原体。尽管HTLV-I会引发这两种疾病，但据报道两者同时发生的情况很少见。本文描述了两例HAM/TSP病例，它们在HAM/TSP发病后发展为淋巴瘤型ATL。在其中一例中，当患者被诊断为HAM/TSP时，通过聚合酶链反应在外周血中检测到相同的HTLV-I感染克隆。这一发现表明，HTLV-I克隆在HAM/TSP阶段就已存在。由于先前已有报道在HAM/TSP患者中频繁检测到HTLV-I感染细胞的克隆增殖，因此需要对HAM/TSP患者进行密切随访。
